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The prognostic impact of human papillomavirus status following treatment failure in oropharyngeal cancer.

The prognostic impact of human papillomavirus status following treatment failure in oropharyngeal cancer.
Author Information (click to view)

Dave E, Ozbek U, Gupta V, Genden E, Miles B, Teng M, Posner M, Misiukiewicz K, Bakst RL,


Dave E, Ozbek U, Gupta V, Genden E, Miles B, Teng M, Posner M, Misiukiewicz K, Bakst RL, (click to view)

Dave E, Ozbek U, Gupta V, Genden E, Miles B, Teng M, Posner M, Misiukiewicz K, Bakst RL,

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PloS one 2017 07 2112(7) e0181108 doi 10.1371/journal.pone.0181108
Abstract
INTRODUCTION
Despite the human papillomavirus conferring a better prognosis in the primary treatment setting, the prognostic impact of viral status after treatment failure in oropharyngeal squamous cell carcinoma patients is poorly understood.

METHODS
We retrospectively identified 33 oropharyngeal squamous cell carcinoma (OPC) patients with local and/or distant disease recurrence post-treatment, and looked at metastatic patterns, time to failure and survival patterns by HPV status.

RESULTS
Median overall survival following local failure was not significantly different by HPV status (17 months for HPV+ vs. 14 months for HPV-, p = 0.23). However, following distant failures, HPV+ patients lived significantly longer than HPV- patients (median 42 months vs. 11 months, p = 0.004). HPV- patients were more likely to have locoregional failures as compared to HPV+ patients (p = 0.005), but the difference in distant failure between both groups was not significant (p = 0.09). HPV+ patients were more likely to develop metastases to sites other than the lung and bones.

CONCLUSION
HPV positivity predicts a favorable prognosis with the potential for long-term survival following distant, not locoregional, failures. These results have important implications for the aggressiveness of treatment and type of surveillance imaging performed.

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