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The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients.

The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients.
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Uygur B, Celik O, Ozturk D, Erturk M, Otcu H, Ustabasıoglu FE, Yıldırım A,


Uygur B, Celik O, Ozturk D, Erturk M, Otcu H, Ustabasıoglu FE, Yıldırım A, (click to view)

Uygur B, Celik O, Ozturk D, Erturk M, Otcu H, Ustabasıoglu FE, Yıldırım A,

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Kardiologia polska 2016 12 13() doi 10.5603/KP.a2016.0167
Abstract
BACKGROUND AND AIM
Epicardial adipose tissue is a metabolically active visceral fat depot which plays an important role in the pathogenesis of coronary atherosclerosis. Due to its asymmetrical distribution, the relation between location-specific epicardial adipose tissue measurements and coronary atherosclerosis remains unclear. Our study investigated the relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden which was detected by coronary computed tomography angiography in Type 2 diabetic patients without coronary artery disease history.

METHODS
A total of 157 consecutive diabetic patients underwent coronary computed tomography angiography were included retrospectively. After an evaluation of the coronary computed tomography angiography images, the study population was divided into two groups according to the presence of coronary atherosclerosis. In both groups, total and left atrioventricular groove epicardial adipose tissue volumes were measured.

RESULTS
Total and left atrioventricular groove epicardial adipose tissue volumes were significantly associated with coronary atherosclerosis, but only left atrioventricular groove epicardial adipose tissue volumes were an independent predictor for coronary artery disease. Also, total and left atrioventricular groove epicardial adipose tissue volumes were positively correlated with C-reactive protein values (p=0.0001/p=0.0001) and the number of coronary atherosclerotic segments (p=0.0001/p=0.0001).

CONCLUSIONS
Left atrioventricular groove epicardial adipose tissue volume is an independent predictor of coronary artery disease in Type 2 diabetic patients without coronary artery disease history. Left atrioventricular groove epicardial adipose tissue volume may be used to identify Type 2 diabetic patients who may require early coronary artery disease intervention because of the potential risk of coronary atherosclerosis.

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