Journal of diabetes investigation 2017 11 16() doi 10.1111/jdi.12777
The association between urine pH and abnormal glucose tolerance in men and women is unclear; therefore, we conducted a community-based, cross-sectional study to investigate sex-specific associations between these values, possible indicators of prediabetes, and type 2 diabetes.
MATERIALS AND METHODS
We enrolled 4,945 Japanese subjects (2,490 men and 2,455 women), who had undergone annual health checkups. To investigate the relationship between low urine pH and abnormal glucose tolerance, subjects were divided into three groups based on their fasting plasma glucose levels (<6.11 mmol/L; 6.11-6.99 mmol/L; and ≥6.99 mmol/L), and three groups based on their HbA1c levels (≤44.3 mmol/mol; 44.3-47.5 mmol/mol; and ≥47.5 mmol/mol). To examine the effects of urine pH on abnormal glucose tolerance, subjects were categorized into five groups based on their urine pH (5.0, 5.5, 6.0, 6.5, and ≥7.0). RESULTS
Multivariate analysis adjusted for age, body mass index, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol, uric acid, creatinine, and anti-diabetic agent use revealed significant associations between low urine pH and both high fasting plasma glucose and high HbA1c levels (P for trend=0.0260, 0.0075) in men. Moreover, after the same adjustments, prevalence rates of abnormal glucose tolerance (≥6.11 mmol/L and ≥6.99 mmol/L), increased significantly as urine pH levels decreased (P for trend=0.0483, 0.0181) in men. In women, a similar trend was observed without a significant difference.
Low urine pH is significantly associated with abnormal glucose tolerance; therefore, measuring urine pH might prove useful for identifying patients at high risk for diabetes. This article is protected by copyright. All rights reserved.