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The relationship of plasma Trans fatty acids with dietary inflammatory index among US adults.

The relationship of plasma Trans fatty acids with dietary inflammatory index among US adults.
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Mazidi M, Gao HK, Shivappa N, Wirth MD, Hebert JR, Kengne AP,


Mazidi M, Gao HK, Shivappa N, Wirth MD, Hebert JR, Kengne AP, (click to view)

Mazidi M, Gao HK, Shivappa N, Wirth MD, Hebert JR, Kengne AP,

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Lipids in health and disease 2017 08 0416(1) 147 doi 10.1186/s12944-017-0527-1
Abstract
BACKGROUND
It has been suggested that trans fatty acids (TFAs) play an important role in cardiovascular diseases. We investigated the association between plasma TFAs and the dietary inflammatory index (DII) ™ in US adults.

METHODS
National Health and Nutrition Examination Survey (NHANES) participants with data on plasma TFAs measured from 1999 to 2010 were included. Energy-adjusted-DII ™ (E-DII ™) expressed per 1000 kcal was calculated from 24-h dietary recalls. All statistical analyses accounted for the survey design and sample weights.

RESULTS
Of the 5446 eligible participants, 46.8% (n = 2550) were men. The mean age of the population was 47.1 years overall, 47.8 years for men and 46.5 years for women (p = 0.09). After adjustment for C-reactive protein, body-mass-index, smoking, race, age, education, and marital status in linear regressions, trans 9-hexadecenoic acid [β coefficient 0.068 (95% CI: 0.032 to 0.188)], trans 11-octadecenoic acid [β coefficient 0.143 (95% CI: 0.155 to 0.310)], trans 9-octadecenoic acid [β coefficient 0.122 (95% CI: 0.120 to 0.277)], trans 9, and trans 12-octadienoic acid [β coefficient 0.103 (95% CI: 0.090 to 0.247)] were positively associated with the DII (all p < 0.001). CONCLUSION
The association of plasma TFAs with a marker of dietary inflammation suggests an underlying mechanism in the initiation and progression of cardiovascular diseases.

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