Journal of clinical research in pediatric endocrinology 2016 12 23() doi 10.4274/jcrpe.3682
The aim of this study was to investigate the relationship between zonulin and clinical laboratory parameters in childhood obesity.
The study included obese children with a body mass index >95th percentile and healthy children who were similar age and gender distribution. Clinical (body mass index, waist circumferences, mid arm circumference, triceps skin fold, percentage of body fat, systolic blood pressure, diastolic blood pressure) and biochemical (glucose, insulin, lipids, thyroid function tests, cortisol, zonulin and leptin levels) parameters were measured.
A total of 43 obese subjects (23 males, mean age: 11.1±3.1 yrs) and 37 healthy subjects (18 males, mean age: 11.5±3.5 yrs) were included in this study. Obese children had significantly higher insulin, HOMA-IR, TG, TC, LDL-C, HDL-C, zonulin and leptin levels than those of the healthy children (p < 0.05), while glucose levels were not different (p > 0.05). Comparison of the obese children regarding the insulin resistance showed no statistically significant differences for zonulin levels (p > 0.05).
To the best of our knowledge, the present study is the first study to compare serum zonulin levels between obese and non-obese children. The results of the study showed that zonulin was significantly higher in obese children when compared to healthy children, which is indicating a potential role of zonulin in the obesity etiopathogenesis and related disturbances.