Advertisement

 

 

The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities.

The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities.
Author Information (click to view)

Mohamed IA, Krishnamoorthy NT, Nasrallah GK, Da'as SI,


Mohamed IA, Krishnamoorthy NT, Nasrallah GK, Da'as SI, (click to view)

Mohamed IA, Krishnamoorthy NT, Nasrallah GK, Da'as SI,

Advertisement

Journal of cellular physiology 2017 02 16232(7) 1650-1659 doi 10.1002/jcp.25639
Abstract

Hypertrophic cardiomyopathy (HCM) is a common autosomal dominant genetic cardiovascular disorder marked by genetic and phenotypic heterogeneity. Mutations in the gene encodes the cardiac myosin-binding protein C, cMYBPC3 is amongst the various sarcomeric genes that are associated with HCM. These mutations produce mutated mRNAs and truncated cMyBP-C proteins. In this review, we will discuss the implications and molecular mechanisms involved in MYBPC3 different mutations. Further, we will highlight the novel targets that can be developed into potential therapeutics for the treatment of HMC. J. Cell. Physiol. 232: 1650-1659, 2017. © 2016 Wiley Periodicals, Inc.

Submit a Comment

Your email address will not be published. Required fields are marked *

five × one =

[ HIDE/SHOW ]