Epigenetic mechanisms play a key role in pathogenesis of asthma, allergic rhinitis, atopic dermatitis, food allergy disorders and other allergic diseases, in particular by environmental factors mediation and recognised allergy-risk modifiers. It aimed to study the recent advances in epigenetics from allergic diseases in a succinct, and thorough manner.

Our understanding of the role of epigenetics in the pathogenesis and clinical image of allergies has been significantly increased in recent years. In particular, epigenetic markings have been found to have a diagnostic ability for atopic sensitise, asthma, allergic rhinitis and food Allergy, in particular DNA methylation. Regulated allergens DNA methylation, like oral food challenges, may be a prediction for therapeutic responses. Additionally, direct or indirect epigenetic pathways, in particular histone changes, were able to benefit the expression of the allergic genes and, usually, to increase airway biodiversity in allergic diseases or their animal models.

More experiments are necessary to investigate and improve the diagnostic and therapeutic ability of allergy epigenetic modifications.

Reference: https://journals.lww.com/co-allergy/Abstract/2020/02000/The_role_of_epigenetics_in_allergy_and_asthma.9.aspx