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The Role of Epithelial-Mesenchymal Transition in Chronic Obstructive Pulmonary Disease.

The Role of Epithelial-Mesenchymal Transition in Chronic Obstructive Pulmonary Disease.
Author Information (click to view)

Courtney JM, Spafford PL,


Courtney JM, Spafford PL, (click to view)

Courtney JM, Spafford PL,

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Cells, tissues, organs 2017 02 20203(2) 99-104 doi 10.1159/000450919
Abstract

Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, and there is currently no treatment that can halt the progression of the disease. Over the last decade there has been increasing interest in the idea that epithelial-mesenchymal transition (EMT) may be active in COPD. Here we review the evidence for EMT in COPD as well as the current progress being made on understanding the drivers and mechanisms involved. Finally, we discuss the potential benefits that understanding EMT may bring to the field of chronic respiratory disease.

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