Allergic skin diseases such as urticaria, atopic dermatitis, and allergic contact dermatitis are among the most common skin diseases with severe socioeconomic consequences. The pathogenesis of allergic skin diseases is complex. This review provides an overview of cytokines IL-17, IL-23, IL-31, and IL-33.

Current research results show a variety of immunological processes in the pathogenesis of allergic skin diseases, including the role of cytokines. In addition to the Th1 and Th2 immune response, the immune response via Th17 is becoming increasingly crucial in allergic skin diseases. The cytokines have been discussed in the literature recently. Different cytokines promote the various symptoms seen in the other allergic skin diseases, including pruritus, dermatitis, mast cell mediator release, and inflammation.

We are still in the early stages of understanding the pathophysiology of allergic skin diseases and the role of various cytokines in the immune system. Researchers can expect different standard therapeutic options to evolve to develop targeted antibodies against the proinflammatory cytokines. Further studies are required to explore the role of IL-17, IL-23, and IL-31, IL-33 in allergic skin diseases.

Reference: https://journals.lww.com/co-allergy/Abstract/2020/08000/The_role_of_IL_17,_IL_23_and_IL_31,_IL_33_in.8.aspx

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