Lymphocytic duodenosis (LD), defined as increased intraepithelial lymphocytes (IELs) per 100 epithelial cells with normal villous architecture, is linked to a variety of gastrointestinal (GI) diseases. Researchers intended to conduct a systematic review and analyse the prevalence and prognosis of LD in children. To identify LD patients and controls, they evaluated all children (18 years old) who had esophagogastroduodenoscopy (EGD) with duodenal biopsy. Demographic, clinical, and pathologic data were analysed and documented. The findings were included in a systematic review. During the course of the research, 12,744 children had EGDs with biopsies. They found 426 children with LD and 474 healthy youngsters among them. The median age was 10.7 years and 12.6 years, with 254 and 278 girls in the LD and control groups, respectively. Abdominal discomfort, gastric acid reflux illness, diarrhoea, and vomiting were the most prevalent presenting symptoms in both groups. The LD and control groups had statistically different levels of diarrhoea and constipation, respectively. In the LD and control groups, the median follow-up is 3.6 months. The LD group had a higher prevalence of CD, Crohn’s disease, and Helicobacter pylori gastritis.

The rate of LD in children is comparable to the rate reported in adults. LD appears to be a benign and transitory histologic feature in children in the absence of Crohn disease, CD, or H. Pylori.