Sleep disturbances are one of the most prevalent nonmotor symptoms of Parkinson’s disease (PD). They can appear in the early stages of the disease and worsen as the disease progresses. Sleep disruptions may contribute to disease progression in addition to being a sign of neurodegeneration. Currently, there are few choices for treating sleep disorders in people with Parkinson’s disease. The cortical and subcortical neurophysiological alterations that impact sleep in PDParkinson’s disease may provide fresh insights into strategies for reversing sleep disturbance. For a review, researchers looked at cortical and subcortical recording investigations of sleep in people with PD, with a special focus on the electrical abnormalities that have been described.

Slow-wave sleep and rapid eye movement sleep were both significantly interrupted in people with PD, according to these researchers. Researchers went through the implications of these electrophysiological alterations, as well as the possibility of modifying PD-related motor and nonmotor symptoms by targeting sleep via stimulation treatment.