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The TP53 gene rs1042522 C>G polymorphism and neuroblastoma risk in Chinese children.

The TP53 gene rs1042522 C>G polymorphism and neuroblastoma risk in Chinese children.
Author Information (click to view)

He J, Wang F, Zhu J, Zhang Z, Zou Y, Zhang R, Yang T, Xia H,


He J, Wang F, Zhu J, Zhang Z, Zou Y, Zhang R, Yang T, Xia H, (click to view)

He J, Wang F, Zhu J, Zhang Z, Zou Y, Zhang R, Yang T, Xia H,

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Aging 2017 03 08() doi 10.18632/aging.101196
Abstract

TP53, a tumor suppressor gene, plays a critical role in cell cycle control, apoptosis, and DNA damage repair. Previous studies have indicated that the TP53 gene Arg72Pro (rs1042522 C>G) polymorphism is associated with susceptibility to various types of cancer. We evaluated the association of the TP53 gene rs1042522 C>G polymorphism with neuroblastoma susceptibility in a hospital-based study among the Chinese Han population. Enrolled were 256 patients and 531 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) generated using logistic regression models were used to determine the strength of the association of interest. No association was detected between rs1042522 C>G polymorphism and neuroblastoma risk. In our stratification analysis of age, gender, sites of origin, and clinical stages, we observed that subjects with rs1042522 CG/GG genotypes had a lower risk of developing neuroblastoma in the mediastinum (Adjusted OR=0.52, 95% CI=0.33-0.82, P=0.005) than those carrying the CC genotype. These results indicate that TP53 gene rs1042522 C>G polymorphism may exert a weak and site-specific effect on neuroblastoma risk in Southern Chinese children and warrant further confirmation.

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