The purpose of this review is to provide an update on the literature related to traffic-related air pollution (TRAP) and allergy illness in terms of global urbanization, since the world’s most populated countries confront serious TRAP exposure issues. As research continues to reveal that gene–environment interactions and epigenetics play a role in the TRAP–allergy connection, evidence for climate change linkages develops. Greenspace may provide a buffer against the negative impacts of traffic on general health, but it also poses dangers in terms of allergy illness.

In terms of supporting observational data and mechanistic research, the relationship between traffic-related pollution and allergies continues to increase. TRAP levels continue to surpass safe levels across the world, particularly in Asia, implying that the associated negative health implications will worsen. This might be mitigated through primary emission reductions and urban design. Attention to the combined effects of TRAP and allergen exposure is essential for avoiding erroneous conclusions based on separate variables.