For a study, the researchers aimed to determine the efficacy of high-dose versus low-dose tranexamic acid (TXA) in adolescent idiopathic scoliosis (AIS) corrective surgery. A total of 166 AIS patients aged between 10 and 21 years, of American Society of Anesthesiologists (ASA) physical status I and II, preoperative hemoglobin more than 10 g/dL, platelet count more than 150,000 cells/L and Cobb angle of more than 45 degrees scheduled for elective single-stage posterior spinal fusion (PSF) surgery by two attending surgeons were taken under consideration between March 2017 and November 2018. The mean total surgical blood loss between the 2 groups was not effective Group A: somewhere between 928.8 and 406.1 mL [range: 348–1857 mL]; Group B: somewhere between 918.1 and 406.2 mL [range: 271–2000 mL], P=0.865). The median duration of surgery is about 120 minutes.  Just one patient in each group received an allogeneic blood transfusion during the perioperative period. No effective changes were determined in hemoglobin and coagulation profile at pre-operation, post-operation 0 hours, and 48 hours. Sex, the number of vertebral levels fused, and the duration of surgery were determined to be independently related to total surgical blood loss. No adverse events were generally observed perioperatively. Low-dose TXA was determined to be as efficacious as high-dose TXA in decreasing blood loss and allogeneic blood transfusion for AIS patients undergoing PSF surgery.