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Transcription factor ZNF148 is a negative regulator of human muscle differentiation.

Transcription factor ZNF148 is a negative regulator of human muscle differentiation.
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Bakke J, Wright WC, Zamora AE, Ong SS, Wang YM, Hoyer JD, Brewer CT, Thomas PG, Chen T,


Bakke J, Wright WC, Zamora AE, Ong SS, Wang YM, Hoyer JD, Brewer CT, Thomas PG, Chen T, (click to view)

Bakke J, Wright WC, Zamora AE, Ong SS, Wang YM, Hoyer JD, Brewer CT, Thomas PG, Chen T,

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Scientific reports 2017 08 157(1) 8138 doi 10.1038/s41598-017-08267-5
Abstract

Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.

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