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Transcriptional repression in macrophages: basic mechanisms and alterations in metabolic-inflammatory diseases.

Transcriptional repression in macrophages: basic mechanisms and alterations in metabolic-inflammatory diseases.
Author Information (click to view)

Treuter E, Fan R, Huang Z, Jakobsson T, Venteclef N,


Treuter E, Fan R, Huang Z, Jakobsson T, Venteclef N, (click to view)

Treuter E, Fan R, Huang Z, Jakobsson T, Venteclef N,

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FEBS letters 2017 09 13() doi 10.1002/1873-3468.12850
Abstract

Macrophage differentiation and signal responses are coordinated by closely linked transcriptional and epigenomic mechanisms that trigger gene expression. In contrast to well-characterized transcriptional activation pathways in response to diverse metabolic and inflammatory signals, we just begin appreciating that transcriptional repression is equally important. Here we will highlight macrophage pathways that are controlled by multifaceted repression events, along with a discussion of underlying regulatory mechanisms and components. We will particularly discuss pro- versus anti-inflammatory action of a fundamental corepressor complex, transcription factor crosstalk, repression at enhancers and during elongation, and diverse corepressor knockout mouse models. We will finally emphasize how alterations of macrophage repression pathways in humans contribute to, or even cause, metabolic-inflammatory diseases such as obesity and type 2 diabetes. This article is protected by copyright. All rights reserved.

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