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Treatment of denture-related stomatitis improves endothelial function assessed by flow-mediated vascular dilation.

Treatment of denture-related stomatitis improves endothelial function assessed by flow-mediated vascular dilation.
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Osmenda G, Maciąg J, Wilk G, Maciąg A, Nowakowski D, Loster J, Dembowska E, Robertson D, Guzik T, Cześnikiewicz-Guzik M,


Osmenda G, Maciąg J, Wilk G, Maciąg A, Nowakowski D, Loster J, Dembowska E, Robertson D, Guzik T, Cześnikiewicz-Guzik M, (click to view)

Osmenda G, Maciąg J, Wilk G, Maciąg A, Nowakowski D, Loster J, Dembowska E, Robertson D, Guzik T, Cześnikiewicz-Guzik M,

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Archives of medical science : AMS 2016 12 1813(1) 66-74 doi 10.5114/aoms.2017.64715
Abstract
INTRODUCTION
The presence of oral inflammation has recently been linked with the pathogenesis of cardiovascular diseases. While numerous studies have described links between periodontitis and endothelial dysfunction, little is known about the influence of denture-related stomatitis (DRS) on cardiovascular risk. Therefore, the aim of this study was to determine whether the treatment of DRS can lead to improvement of the clinical measures of vascular dysfunction.

MATERIAL AND METHODS
The DRS patients were treated with a local oral antifungal agent for 3 weeks. Blood pressure, flow-mediated dilatation (FMD) and nitroglycerine-mediated vascular dilatation (NMD) were measured during three study visits: before treatment, one day and two months after conclusion of antifungal therapy.

RESULTS
Flow-mediated dilatation measurements showed significant improvement of endothelial function 2 months after treatment (FMD median 5%, 95 CI: 3-8.3 vs. 11%, 95% CI: 8.8-14.4; p < 0.01), while there was no difference in control, endothelium-independent vasorelaxations (NMD; median = 15.3%, 95% CI: 10.8-19.3 vs. 12.7%, 95% CI: 10.6-15; p = 0.3). Other cardiovascular parameters such as systolic (median = 125 mm Hg; 95% CI: 116-129 vs. 120 mm Hg, 95% CI: 116-126; p = 0.1) as well as diastolic blood pressure and heart rate (median = 65.5 bpm, 95% CI: 56.7-77.7 vs. 71 bpm, 95% CI: 66.7-75; p = 0.5) did not change during or after the treatment. CONCLUSIONS
Treatment of DRS is associated with improvement of endothelial function. Since endothelial dysfunction is known to precede the development of severe cardiovascular disorders such as atherosclerosis and hypertension, patients should be more carefully screened for DRS in general dental practice, and immediate DRS treatment should be advised.

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