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Triglycerides and blood pressure in relation to circulating CD34-positive cell levels among community-dwelling elderly Japanese men: a cross-sectional study.

Triglycerides and blood pressure in relation to circulating CD34-positive cell levels among community-dwelling elderly Japanese men: a cross-sectional study.
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Shimizu Y, Sato S, Noguchi Y, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri SY, Nagata Y, Maeda T,


Shimizu Y, Sato S, Noguchi Y, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri SY, Nagata Y, Maeda T, (click to view)

Shimizu Y, Sato S, Noguchi Y, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri SY, Nagata Y, Maeda T,

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Environmental health and preventive medicine 2017 11 2122(1) 77 doi 10.1186/s12199-017-0684-x
Abstract
BACKGROUND
Triglycerides are reported to be positively associated with blood pressure (both systolic and diastolic). However, in a previous study, we reported a significant positive association between triglycerides and circulating CD34-positive cells (endothelial repair) among non-hypertensive, but not hypertensive, participants. Since hypertension and endothelial dysfunction have a bi-directional association (vicious cycle), the status of circulating CD34-positive cells may influence the association between triglycerides and hypertension.

METHODS
Since antihypertensive medication use may influence results of the present study, we conducted a cross-sectional study of 327 community dwelling elderly (aged 60-69 years) Japanese participants who were not taking anti-hypertensive medication and who had participated in a general health check-up in 2013-2015.

RESULTS
Participants were classified into two groups based on median values of circulating CD34-positive cells (0.93 cells/μL). For participants with lower circulating CD34-positive cells (n = 165), a significant positive association was seen between triglycerides and blood pressure, but not for participants with higher circulating CD34-positive cells (n = 162). The multivariable standardized parameter estimates (β) and p values of systolic blood pressure and diastolic blood pressure were 0.23 (p = 0.007) and 0.18 (p = 0.036) for participants with lower circulating CD34-positive cells and 0.08 (p = 0.409) and 0.03 (p = 0.786) for those with higher circulating CD34-positive cells.

CONCLUSION
A significant positive association between triglycerides and blood pressure exists among those with lower, but not higher, circulating CD34-positive cells. The level of circulating CD34-positive cells acts as a determinant factor for the association between triglycerides and blood pressure.

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