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Enzyme-targeted modulation offers novel promise for enhancing skin tone and texture. 

A study published in June 2025 issue of Frontiers in Medicine highlighted the critical role of tyrosine kinases (TKs) in regulating key cellular processes involved in dermatologic conditions.  

Researchers explored how TKs influenced pigmentation, aging, and inflammation in dermatologic conditions, aiming to clarify their underlying mechanisms and therapeutic relevance.  

They reviewed recent publications assessing the effects of tyrosine kinase inhibitors (TKIs) on skin pigmentation and elasticity and analyzed data on the role of TKIs in minimizing hyperpigmentation and enhancing dermal elasticity. The clinical challenges were also examined, including inconsistent treatment outcomes and the risk of adverse effects, to evaluate the therapeutic viability of TKIs in dermatologic care.  

The results showed that TKIs reduced pigmentation by up to 30% in certain hyperpigmentation disorders and improved skin elasticity by around 15% in anti-aging contexts. The findings also indicated challenges such as inconsistent effectiveness among different patient groups and adverse effects, including skin irritation and systemic toxicity.  

Investigators concluded that TKs held therapeutic promise in dermatology, but optimizing TKI use required addressing variable efficacy and safety concerns. 

Source: onlinelibrary.wiley.com/doi/10.1111/jocd.70143