A heart failure treatment using umbilical cord-derived stem cells may lead to notable improvements in heart muscle function and quality of life, according to a new study published in Circulation Research, an American Heart Association journal.
“We are encouraged by our findings because they could pave the way to a non-invasive, promising new therapy for a group of patients who face grim odds,” said study corresponding author Fernando Figueroa, M.D., professor of medicine at the Universidad de los Andes in Chile.
In this trial, 30 patients, ages 18 to 75, with stable heart failure receiving optimal drug therapy underwent intravenous infusions with either umbilical cord-derived stem cells or placebo. The umbilical cords were obtained from full-term human placentas from healthy donors by caesarean section after informed consent. Compared to the placebo treatment, the stem cell therapy:
- showed sustained and “significant” improvement in the hearts’ ability to pump blood in the year following treatment;
- resulted in greater improvements on measures of daily functional status and quality of life; and
- was safe with no adverse effects or development of alloantibodies, a common immune complication in patients receiving organ transplants or blood transfusions.