Utilizing data obtained from a prospective international juvenile systemic sclerosis cohort (jSScC) to determine if pulmonary screening with forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO) is sufficient to assess the presence of interstitial lung disease (ILD) in comparison to high resolution computed tomography (HRCT) in jSSc. The jSScC cohort database was queried for patients enrolled from January 2008 to January 2020 with recorded pulmonary function tests (PFT) parameters and HRCT to determine the discriminatory properties of PFTs parameters, FVC, and DLCO, in detecting ILD.
Eighty‐six jSSc patients had both CT imaging and FVC values for direct comparison. Using findings on HRCT as the standard measure of ILD presence, the sensitivity of FVC in detecting ILD in jSSc was only 40%, the specificity was 77%, and AUC was 0.58. The sensitivity of DLCO in detecting ILD was 76%, the specificity was 70%, and AUC was 0.73.
In conclusion, the performance of PFTs in jSSc to detect underlying ILD was quite limited. Specifically, the FVC, which is one of the leading clinical parameters in adult SSc to detect and monitor ILD, would miss approximately 60% of children with ILD changes on their accompanying HRCT.