Abundant evidence points to a critical role for antibodies in protection and pathology across infectious diseases. While the antibody variable domain facilitates antibody binding and the blockade of infection, the constant domain (Fc) mediates cross-talk with the innate immune system. The biological activity of the Fc region is controlled genetically via class switch recombination, resulting in the selection of distinct antibody isotypes and subclasses. However, a second modification is made to all antibodies, via post-translational changes in antibody glycosylation. Studies from autoimmunity and oncology have established the role of IgG Fc glycosylation as a key regulator of humoral immune activity. However, a growing body of literature, exploring IgG Fc glycosylation through the lens of infectious diseases, points to: the role of inflammation in shaping Fc glycan profiles, the remarkable immune plasticity in antibody glycosylation across pathogen exposed populations, canonical and non-canonical functions of glycans, and the existence of antigen-specific control over antibody Fc glycosylation. Ultimately, this work provides critical new insights into the functional roles for antibody glycosylation, as well as lays the foundation for leveraging antibody glycosylation to drive prevention or control across diseases.© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: email@example.com.
More beads, more peristaltic reserve, better outcomes: factors predicting postoperative dysphagia after magnetic sphincter augmentation.
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