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Use of Cellular Decapping Activators by Positive-Strand RNA Viruses.

Use of Cellular Decapping Activators by Positive-Strand RNA Viruses.
Author Information (click to view)

Jungfleisch J, Blasco-Moreno B, Díez J,


Jungfleisch J, Blasco-Moreno B, Díez J, (click to view)

Jungfleisch J, Blasco-Moreno B, Díez J,

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Viruses 2016 12 218(12) pii E340
Abstract

Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5′-3′ mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus.

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