Vaccination rejection has grown in Turkey in recent years, according to primary care providers. The current study sought to ascertain the incidence of vaccine rejection and hesitation in Turkey, as well as demographic characteristics and underlying causes. The current descriptive cross-sectional study was carried out in Istanbul and Tekirdag, two major Turkish cities with high rates of internal migration. To replicate Turkey’s demographic composition, 1004 participants were chosen by cluster sampling based on birthplace, age, and level of education among all persons who attended family medicine outpatient clinics at Namik Kemal University and işli Hamidiye Etfal Training and Research Hospital.

Face-to-face questionnaires were utilised. Data reveal that this drop was mostly caused by an increase in vaccination refusal and reluctance, with distrust of vaccine makers identified as the most relevant factor. Individuals who exhibit vaccination rejection and reluctance are most likely to have been born in Turkey’s developed geographical regions and to have a high income and educational level. According to these findings, vaccination rates in Turkey will decline in the future years.