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Vaccine resistant pseudorabies virus causes mink infection in China.

Vaccine resistant pseudorabies virus causes mink infection in China.
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Wang GS, Du Y, Wu JQ, Tian FL, Yu XJ, Wang JB,


Wang GS, Du Y, Wu JQ, Tian FL, Yu XJ, Wang JB, (click to view)

Wang GS, Du Y, Wu JQ, Tian FL, Yu XJ, Wang JB,

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BMC veterinary research 2018 01 1914(1) 20 doi 10.1186/s12917-018-1334-2
Abstract
BACKGROUND
Pseudorabies, a highly contagious infectious disease of swine is caused by pseudorabies virus (PRV). PRV can cause fatal infection in other animal species.

RESULTS
We report a deadly outbreak of pseudorabies that killed 87.2% (3522/4028) minks in a farm in 2014 in Shandong Province, China. PRV was isolated by using Vero cell culture and detected in mink samples by PCR from minks died during the outbreak. Epidemiological analysis indicated that 5.8% of minks (33/566) were PCR positive to PRV in Shandong Province. Phylogenetic analysis indicated that the PRV strains isolated from minks in this study were in the same clade with the Chinese porcine PRV isolates, which are resistant to the PRV vaccine.

CONCLUSIONS
We demonstrated that pseudorabies virus caused an outbreak of minks in a farm in Shandong Province of China and the virus has a very high infection rate in minks in Shandong Province, which is a challenge for the fur industry in China.

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