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Varicella-Zoster Virus Infections In Pediatric Malignancy Patients: A 7-Year Analysis.

Varicella-Zoster Virus Infections In Pediatric Malignancy Patients: A 7-Year Analysis.
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Düzgöl M, Özek G, Bayram N, Oymak Y, Kara A, Demirağ B, Karapınar TH, Ay Y, Vergin C, Devrim İ,


Düzgöl M, Özek G, Bayram N, Oymak Y, Kara A, Demirağ B, Karapınar TH, Ay Y, Vergin C, Devrim İ, (click to view)

Düzgöl M, Özek G, Bayram N, Oymak Y, Kara A, Demirağ B, Karapınar TH, Ay Y, Vergin C, Devrim İ,

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Turkish journal of haematology : official journal of Turkish Society of Haematology 2016 Oct 18() doi 10.4274/tjh.2016.0046
Abstract

Primary Varicella Zoster Virus infection is a benign self-limited disease. In this study, we aimed to review our experience with focusing on the outcome and treatment of the varicella zoster virus (VZV) infection in pediatric malignancy patients. During the study period; a total of 41 patients with pediatric malignancy had been hospitalized with the diagnosis of VZV infection. All the patients were treated with intravenous acyclovir for a median of 7 days (ranging from 5 to 21 days). The calculated attributable delay of chemotherapy due to VZV infections was 8 days (ranging from 2 to 60 days). VZV related complications were observed in 3 of 41 (7%) patients, of whom suffered from acute respiratory distress syndrome and one of them with hemophagocytic lymphohistiocytosis had died due to the respiratory failure despite acyclovir and broad spectrum antimicrobial treatment plus supportive treatment. VZV infections are still important contagious disease in pediatric cancer patients, because they cause not only significant mortality, but also a delay in their chemotherapy.

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