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Viral Interactions with Host Cell Rab GTPases.

Viral Interactions with Host Cell Rab GTPases.
Author Information (click to view)

Spearman P,


Spearman P, (click to view)

Spearman P,

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Small GTPases 2017 07 11() 0 doi 10.1080/21541248.2017.1346552

Abstract

Viruses are obligate intracellular parasites that utilize cellular machinery for many aspects of their replication cycles. Enveloped viruses generally rely upon host vesicular trafficking machinery to direct their structural proteins and genomes to sites of virus replication, assembly, and budding. Rab GTPases have been implicated in the replication of many important viral pathogens infecting humans. This review provides a summary of virus-Rab protein interactions, with a particular focus on the role of Rab-related trafficking pathways on late events in the lifecycle of herpesviruses and of HIV-1.

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