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Viral manipulation of STAT3: Evade, exploit, and injure.

Viral manipulation of STAT3: Evade, exploit, and injure.
Author Information (click to view)

Roca Suarez AA, Van Renne N, Baumert TF, Lupberger J,


Roca Suarez AA, Van Renne N, Baumert TF, Lupberger J, (click to view)

Roca Suarez AA, Van Renne N, Baumert TF, Lupberger J,

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PLoS pathogens 2018 03 1514(3) e1006839 doi 10.1371/journal.ppat.1006839
Abstract

Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.

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