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Viral Oncology: Molecular Biology and Pathogenesis.

Viral Oncology: Molecular Biology and Pathogenesis.
Author Information (click to view)

Mui UN, Haley CT, Tyring SK,


Mui UN, Haley CT, Tyring SK, (click to view)

Mui UN, Haley CT, Tyring SK,

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Journal of clinical medicine 2017 11 296(12) pii 10.3390/jcm6120111

Abstract

Oncoviruses are implicated in approximately 12% of all human cancers. A large number of the world’s population harbors at least one of these oncoviruses, but only a small proportion of these individuals go on to develop cancer. The interplay between host and viral factors is a complex process that works together to create a microenvironment conducive to oncogenesis. In this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed. Currently, there are seven recognized human oncoviruses, which include Epstein-Barr Virus (EBV), Human Papillomavirus (HPV), Hepatitis B and C viruses (HBV and HCV), Human T-cell lymphotropic virus-1 (HTLV-1), Human Herpesvirus-8 (HHV-8), and Merkel Cell Polyomavirus (MCPyV). Available and emerging therapies for these oncoviruses will be mentioned.

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