There are not many information on the virological characterisation of patients with inability to current-age direct-acting antivirals (DAAs), specifically elbasvir/grazoprevir, sofosbuvir/velpatasvir and glecaprevir/pibrentasvir. This investigation meant to portray virological examples in patients with inability to current DAA regimens just as the viability of re-treatment. Every one of the 61 back to back hepatitis C infection (HCV) treatment-guileless patients with inability to current DAAs from January 2018 to February 2019 were selected. Sanger sequencing of NS3, NS5A and NS5B proteins was performed utilizing hand crafted conventions. NS5A obstruction related replacements (RASs) were more incessant in the 17 patients treated with sofosbuvir/velpatasvir (89.5%) and 33 patients treated with elbasvir/grazoprevir (97%) contrasted and the 11 patients treated with glecaprevir/pibrentasvir (18.2%) (P = 0.002 and 0.000, separately).

NS3 RASs were all the more regularly identified in the 33 patients with inability to elbasvir/grazoprevir (30.3%) than in the 11 patients treated with glecaprevir/pibrentasvir (9.1%). Pervasiveness of opposition related replacements (RASs) was high in HCV NS5A in 61 patients who bombed current DAAs. 73% of glecaprevir/pibrentasvir-treated patients didn’t show RASs in any HCV areas, more than with other DAAs. Every one of the 21 patients re-treated with sofosbuvir/velpatasvir and voxilaprevir accomplished SVR12.

Reference link- https://www.sciencedirect.com/science/article/abs/pii/S0924857920302375