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Virucidal activity of a quaternary ammonium compound associated with calcium hydroxide on avian influenza virus, Newcastle disease virus, and infectious bursal disease virus.

Virucidal activity of a quaternary ammonium compound associated with calcium hydroxide on avian influenza virus, Newcastle disease virus, and infectious bursal disease virus.
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Ito M, Alam MS, Suzuki M, Takahashi S, Komura M, Sangsriratakul N, Shoham D, Takehara K,


Ito M, Alam MS, Suzuki M, Takahashi S, Komura M, Sangsriratakul N, Shoham D, Takehara K, (click to view)

Ito M, Alam MS, Suzuki M, Takahashi S, Komura M, Sangsriratakul N, Shoham D, Takehara K,

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The Journal of veterinary medical science 2018 03 14() doi 10.1292/jvms.18-0006
Abstract

A quaternary ammonium compound (QAC) was evaluated for its virucidal efficacies with food additive grade calcium hydroxide (FdCa(OH)). When the QAC was diluted 1:500 (QACx500) with redistilled water (dW), it inactivated avian influenza virus (AIV) within 30 sec at 25°C, while at 2°C, it required 1 hr for inactivation. When FdCa(OH)powder was added to QACx500 at a final concentration of 0.17%, the mixture, namely Mix500, inactivated AIV within 3 min at 2°C. After contamination with 1% fetal bovine serum (FBS), Mix500 inactivated AIV within 2 hr at 2°C, but QACx500 did not. These results indicate synergistic effects of the QAC and FdCa(OH)solutions on virucidal activity.

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