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Virus Infection and Death Receptor-Mediated Apoptosis.

Virus Infection and Death Receptor-Mediated Apoptosis.
Author Information (click to view)

Zhou X, Jiang W, Liu Z, Liu S, Liang X,


Zhou X, Jiang W, Liu Z, Liu S, Liang X, (click to view)

Zhou X, Jiang W, Liu Z, Liu S, Liang X,

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Viruses 2017 10 279(11) pii E316
Abstract

Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor necrosis factor family mediate this process. They either assist persistent viral infection or elicit the elimination of infected cells by the host. Death receptor-mediated apoptosis plays an important role in viral pathogenesis and the host antiviral response. Many viruses have acquired the capability to subvert death receptor-mediated apoptosis and evade the host immune response, mainly by virally encoded gene products that suppress death receptor-mediated apoptosis. In this review, we summarize the current information on virus infection and death receptor-mediated apoptosis, particularly focusing on the viral proteins that modulate death receptor-mediated apoptosis.

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