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Vitamin D and Gestational Diabetes Mellitus: A Systematic Review Based on Data Free of Hawthorne Effect.

Vitamin D and Gestational Diabetes Mellitus: A Systematic Review Based on Data Free of Hawthorne Effect.
Author Information (click to view)

Zhang Y, Gong Y, Xue H, Xiong J, Cheng G,


Zhang Y, Gong Y, Xue H, Xiong J, Cheng G, (click to view)

Zhang Y, Gong Y, Xue H, Xiong J, Cheng G,

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BJOG : an international journal of obstetrics and gynaecology 2017 12 15() doi 10.1111/1471-0528.15060
Abstract
BACKGROUND
Gestational diabetes mellitus (GDM) is an increasingly prevalent disorder, associated with low blood vitamin D (VD) level.

OBJECTIVES
To evaluate the relationship between VD and GDM.

SEARCH STRATEGY
EMBASE, MEDLINE, Cochrane library and China Biology Medicine disc were searched till May 2017. The references of previous studies were screened.

SELECTION CRITERIA
Observational studies on the relationship between VD and GDM free from Hawthorne effect and randomized controlled trials of VD supplementation during pregnancy for preventing or treating GDM were included.

DATA COLLECTION AND ANALYSIS
Data and information of included articles were extracted by duplicate using piloted tables. Newcastle-Ottawa Scale and Cochrane Handbook were used for quality assessment. Random-effects models were used for meta-analyses. Heterogeneity tests, sensitive analysis, and analysis of publication bias were conducted.

MAIN RESULTS
Eighty-seven observational studies and 25 randomized controlled trials involving 55859 and 2445 subjects respectively were included. Low blood VD level during pregnancy was associated with a higher risk of GDM (OR = 1.850, 95% CI: 1.471, 2.328). Blood VD level for subjects with GDM were lower than the controls. Blood VD level was associated with fasting plasma glucose (FPG) and HOMA-IR (r = -0.100 and -0.351), whereas the correlation between blood VD level and fasting insulin (FINS) might be concealed by publication bias. VD intervention during pregnancy could change blood level of VD, FINS, FPG, HOMA-IR, glutathione, C-reactive protein, and lipid.

CONCLUSIONS
Low blood VD level could increase the risk of GDM, and VD supplementation during pregnancy could ameliorate the condition of GDM. This article is protected by copyright. All rights reserved.

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