Vitamin D supplementation did not impact kidney outcomes among individuals at high risk for type 2 diabetes (T2D), according to a study published in the Clinical Journal of the American Society of Nephrology. Investigators examined the eff ect of vitamin D supplementation on kidney outcomes among adults who were overweight/ obese and had a high risk for T2D. A total of 2,166 participants were randomly assigned to vitamin D3 or placebo for a median of 2.9 years. Researchers identifi ed 28 cases of worsening of the Kidney Disease: Improving Global Outcomes risk score in the vitamin D group compared with 30 cases in the placebo group (HR, 0.89; 95% CI, 0.52-1.52).The mean difference in eGFR from baseline was −1.0 mL/min/ 1.73 m2 in the vitamin D group and −0.1 mL/ min/1.73 m2 in the placebo group (between group diff erence, −1.0 mL/min/1.73 m2 ; 95% CI, −1.4 to −0.6). In the vitamin D and placebo groups, the mean diff erences in urine albumin to-creatinine ratios were 2.7 mg/g and 2.0 mg/g, respectively (between group diff erence, 0.7 mg/g; 95% CI, −1.5 to 2.9).