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Vortioxetine: A new alternative for the treatment of major depressive disorder.

Vortioxetine: A new alternative for the treatment of major depressive disorder.
Author Information (click to view)

Salagre E, Grande I, Solé B, Sanchez-Moreno J, Vieta E,


Salagre E, Grande I, Solé B, Sanchez-Moreno J, Vieta E, (click to view)

Salagre E, Grande I, Solé B, Sanchez-Moreno J, Vieta E,

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Revista de psiquiatria y salud mental 2017 08 08() pii S1888-9891(17)30092-7
Abstract

Major Depressive Disorder (MDD) is a serious psychiatric condition. Its treatment remains a challenge nowadays. Vortioxetine is a novel antidepressant with a unique profile, as it acts as a multimodal serotoninergic agent. Its efficacy in MDD has been established in many short- and long-term studies, with 7 positive, 4 negative and 1 failed randomized controlled trials. Moreover, its ability to modulate a wide range of neurotransmitters (serotonin, dopamine, norepinephrine, histamine, glutamate or GABA) confers vortioxetine pro-cognitive effects. Side effects are also different from conventional antidepressants, according to its low incidence of sexual dysfunction, weight gain or cardiovascular alterations. The aim of this systematic review is to describe the pharmacology, clinical efficacy and safety profile of vortioxetine, as well as its potential effectiveness in improving cognitive symptoms.

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