Data presented at prior CMSC meetings described baseline, 1-year, and 2-year results of the Multiple Sclerosis Achievement Center, which assessed day wellness programs targeting physical, cognitive, and social well-being in patients with MS. In the present analysis, researchers aimed to establish, using patient-reported outcome (PRO) measures, if the programs improved disease impact and QOL over 3 years. The study team obtained baseline PRO measures for 110 people with MS (PwMS). From the original cohort of 110, they also collected 2-year data for 86 PwMS and 3-year data for 62 PwMS. Outcome measures included the MS Impact Scale (MSIS-29), the Multiple Sclerosis Self-Efficacy Scale-10 item (MSSE), the Godin Leisure Time Exercise Questionnaire, and sections of the Neuro-QoL. The investigators observed associations between reports of Self-Efficacy, Anxiety, Ability to Participate, and Positive Affect in both 1- and 2-year analyses. Evaluation from baseline showed improvement in the Neuro-QoL sections Ability to Participate for year 2 (P=.02) and year 3 (P=.004) and Social Roles for year 2 (P=.001) and year 3 (P=.004). Additional findings at 3 years included significant changes in MSSE (P=.02) and MSIS (P=.03). NeuroQoL measures Depression and Emotional Behavioral Dyscontrol were not significant compared with baseline but were significant compared with 1-year scores.