This descriptive study aimed to identify factors that can influence the quality of life of psoriasis patients. A total of 118 psoriasis outpatients completed a questionnaire consisting of the Dermatology Life Quality Index (DLQI), Psoriasis Life Stress Inventory (PLSI), Mishel Uncertainty in Illness Scale-Community form (MUIS-C), Center for Epidemiologic Studies-Depression scale (CES-D), and Self-Reported Severity Score (SRSS). The Psoriasis Area Severity Index (PASI) was calculated. The collected data were analyzed by descriptive statistics, -test, one-way ANOVA, Scheffé test, Pearson’s correlation analysis, and stepwise multiple regression using SPSS/WIN 26.0. The average score of the DLQI was 14.19 ± 6.83 (range 0-30); the DLQI showed statistically significant differences according to age (F = 4.02, = 0.021) and smoking type (F = 7.49, = 0.001). The dermatology-related quality of life was significantly affected by psoriasis-related stress (β = 0.37, < 0.001), depression (β = 0.35, < 0.001), and subjective severity (β = 0.19, = 0.005); these variables explained 60.7% of the variance in the dermatology-related quality of life (F = 61.34, < 0.001). The results demonstrated that psoriasis-related stress, depression, and perceived severity of psoriasis should be considered when developing nursing interventions to improve patients' quality of life.