Wireless In Situ Catalytic Electron Signaling-Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas.

May 12, 2025

Experts: Hoi Man Iao,Chih-Ying Chen,Ya-Hui Lin,Wan-Chi Pan,Chun-Yi Liang,Hsiu-Ching Liu,Lo-Jei Ching,Pei-Yu Weng,Min-Ren Chiang,Ru-Siou Hsu,Tsu-Chin Chou,I-Chi Lee,Lun-De Liao,Li-An Chu,Shih-Hwa Chiou,Shang-Hsiu Hu

Electron signaling and oxygen level are vital for regulating neural-cell fate and brain recovery. However, clinical challenges arise from the short half-life and the difficulty of spatiotemporally controlled oxygen release and electric signals. In this study, a wireless-charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on-demand O release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood vessels and neurons in vivo. SOCO also reduces TBI glial scarring by reducing activated microglia and stellate cells, promoting infiltration of new neurons. In whole-brain analyses, effective somatostatin (Sst) production inhibits gamma-aminobutyric acid (GABA) synthesis in injured areas, thereby improving brain function and behavioral recovery. Furthermore, spatial multiomics combined with single-cell deconvolution analysis reveals the treatment reprogramming in vivo brain transcriptome of angiogenic markers (Il1a, Lgals3) and GABAergic pathway via modulation of GAD65/67 activity, guiding angiogenesis and neuronal regeneration. This in situ catalytic SOCO with noncontact AMF presents an “electromagnetic messenger”-based therapeutics for reprogramming the neuro-regeneration and brain function recovery in TBI.
© 2025 The Author(s). Advanced Science published by Wiley‐VCH GmbH.

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ABOUT THE EXPERTS

Hoi Man Iao,Chih-Ying Chen,Ya-Hui Lin,Wan-Chi Pan,Chun-Yi Liang,Hsiu-Ching Liu,Lo-Jei Ching,Pei-Yu Weng,Min-Ren Chiang,Ru-Siou Hsu,Tsu-Chin Chou,I-Chi Lee,Lun-De Liao,Li-An Chu,Shih-Hwa Chiou,Shang-Hsiu Hu

Hoi Man Iao

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Chih-Ying Chen

Department of Medical Research, Taipei Veterans General Hospital, Taipei, 112201, Taiwan.

Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.

Ya-Hui Lin

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Brain Research Center, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Wan-Chi Pan

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Chun-Yi Liang

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Hsiu-Ching Liu

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Lo-Jei Ching

Department of Medical Research, Taipei Veterans General Hospital, Taipei, 112201, Taiwan.

Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.

Pei-Yu Weng

Brain Research Center, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Min-Ren Chiang

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Ru-Siou Hsu

Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.

Tsu-Chin Chou

Institute of Analytical and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

I-Chi Lee

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Lun-De Liao

Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County, 35053, Taiwan.

Li-An Chu

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.

Shih-Hwa Chiou

Department of Medical Research, Taipei Veterans General Hospital, Taipei, 112201, Taiwan.

Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.

Shang-Hsiu Hu

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Department of Medical Research, Taipei Veterans General Hospital, Taipei, 112201, Taiwan.

Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.