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Zwitterionic Manganese and Gadolinium Metal-Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging.

Zwitterionic Manganese and Gadolinium Metal-Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging.
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Qin L, Sun ZY, Cheng K, Liu SW, Pang JX, Xia LM, Chen WH, Cheng Z, Chen JX,


Qin L, Sun ZY, Cheng K, Liu SW, Pang JX, Xia LM, Chen WH, Cheng Z, Chen JX, (click to view)

Qin L, Sun ZY, Cheng K, Liu SW, Pang JX, Xia LM, Chen WH, Cheng Z, Chen JX,

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ACS applied materials & interfaces 2017 11 16() doi 10.1021/acsami.7b09608
Abstract

Two water-stable three-dimensional Mn- and Gd-based metal-organic frameworks (MOFs), {[Mn2(Cmdcp)2(H2O)2]·H2O}n (1) and {[Gd(Cmdcp)(H2O)3](NO3)·3H2O}n (2, H3CmdcpBr = N-(4-carboxy benzyl)-(3,5-dicarboxyl)pyridinium bromide), have been prepared and analyzed. In vitro magnetic resonance imaging indicated that MOFs 1 and 2 possess relaxivity r1 values of 17.50 and 13.46 mM(-1)·S(-1), respectively, which are superior to that of the control Gd-DTPA (r1 = 4.87 mM(-1)·S(-1), DTPA = diethylene triamine pentaacetate). MOFs 1 and 2 also possessed good biocompatibility and low cytotoxicity against a model cell line. In vivo magnetic resonance images of treated Kunming mice indicated that kidneys showed remarkably positive signal enhancement after 15 min with intravenous administration of MOF 1 and the hyperintensity of both kidneys persisted for about 240 min with no obvious tissue damage. MOF 1 is therefore promising in vivo probes for imaging intravascular diseases and renal dysfunction.

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