Teen Boy Suffers Serious Burns After ‘Hot Water Challenge’
Other children have also been seriously burned while participating in this ‘fad’
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Month: July 2018
AMA Opposes Proposed Cuts, Gag Orders for Reproductive Health
Cuts to Title X would limit poor, uninsured women’s access to reproductive health care
Read MoreGlucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
Nature 2018 07 18559(7715) 637-641 doi 10.1038/s41586-018-0350-5 Abstract Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood glucose levels and frequently associated with life-threatening...
Read MoreIbrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis.
Blood 2018 07 18() pii 10.1182/blood-2017-12-823393 Abstract
Read MoreShieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
Nature cell biology 2018 07 1820(8) 954-965 doi 10.1038/s41556-018-0140-1 Abstract BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP)...
Read MoreAuthor Correction: Quantification of subclonal selection in cancer from bulk sequencing data.
Nature genetics 2018 07 18() doi 10.1038/s41588-018-0169-x Abstract In the version of this article originally published, in the "Theoretical framework of subclonal selection" section of the main text, ref. 11 instead...
Read MorePerinatal Marijuana Use and the Developing Child.
JAMA 2018 07 16() doi 10.1001/jama.2018.8401 Abstract
Read MoreCorrection to: Andexanet Alfa: First Global Approval.
Drugs 2018 07 21() doi 10.1007/s40265-018-0954-y Abstract The article Andexanet Alfa: First Global Approval, written by Young-A Heo, was originally published Online First without open access.
Read MoreA complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy.
Nature communications 2018 07 189(1) 2794 doi 10.1038/s41467-018-05273-7 Abstract Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while...
Read MoreRepair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
Nature biotechnology 2018 07 16() doi 10.1038/nbt.4192 Abstract CRISPR-Cas9 is poised to become the gene editing tool of choice in clinical contexts. Thus far, exploration of Cas9-induced genetic alterations has been limited to...
Read More53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.
Nature 2018 07 18() doi 10.1038/s41586-018-0324-7 Abstract In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair-which requires a 3′ overhang-and classical non-homologous...
Read MoreReducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells.
Cancer immunology research 2018 07 20() pii 10.1158/2326-6066.CIR-17-0405 Abstract The success of chimeric antigen receptor (CAR)-mediated immunotherapy in acute lymphoblastic leukemia (ALL) highlights the potential of T-cell...
Read MoreAccumulation of succinate controls activation of adipose tissue thermogenesis.
Nature 2018 07 18() doi 10.1038/s41586-018-0353-2 Abstract Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease. Thermogenic respiration is initiated by...
Read MoreThe Brain-Gut-Microbiome Axis.
Cellular and molecular gastroenterology and hepatology 2018 04 126(2) 133-148 doi 10.1016/j.jcmgh.2018.04.003 Abstract Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis....
Read MoreThe influence of connective tissue growth factor on rabbit ligament injury repair.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2017 04 2825(4) 498-503 doi 10.1016/j.jsps.2017.04.013 Abstract OBJECTIVES The injured anterior cruciate ligament (ACL) is deemed...
Read MoreCPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 07 19() JCO2017776112 doi 10.1200/JCO.2017.77.6112 Abstract Purpose CPX-351 is a dual-drug liposomal encapsulation of cytarabine...
Read MoreAbnormal RNA stability in amyotrophic lateral sclerosis.
Nature communications 2018 07 209(1) 2845 doi 10.1038/s41467-018-05049-z Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein...
Read MoreHigh-quality genomes reveal new differences between the great apes.
Nature 559(7714) 336-338 doi 10.1038/d41586-018-05679-9 Abstract
Read MoreLeukaemia hijacks a neural mechanism to invade the central nervous system.
Nature 2018 07 18() doi 10.1038/s41586-018-0342-5 Abstract Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours,...
Read MoreThe influence of connective tissue growth factor on rabbit ligament injury repair.
Bone & joint research 6(7) 399-404 doi 10.1302/2046-3758.67.BJR.2016-0255.R1 Abstract OBJECTIVES The injured anterior cruciate ligament (ACL) is thought to exhibit an impaired healing response, and attempts at surgical...
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