Imaging with MRI identifies active SPMS The presence of cortical lesions at diagnosis in patients with multiple sclerosis proved to be strongly predictive of conversion to secondary progressive MS (SPMS) and disability in a...
Quantification may help stratify SUDEP risk People who died due to sudden unexpected death in epilepsy (SUDEP) had changes in frequency-domain measures of heart rate variability compared with living epilepsy controls, a...
Phase III study fails after promising early data Deutetrabenazine was not effective in treating tics associated with Tourette syndrome, the phase III ARTISTS 2 trial found.At week 8, the difference in Yale Global Tic Severity...
Vaccination timing, additional doses merit consideration Some disease-modifying treatments (DMTs) used in multiple sclerosis (MS) may attenuate patients’ immune response to SARS-CoV-2 vaccination.The American Academy of...
Treatment with S1P Modulators, anti-CD20 linked to poor IgG response Among multiple sclerosis (MS) patients on disease-modifying therapies (DMTs), treatment with sphingosine-1-phosphate receptor modulators (S1P) and anti-CD20...
Exposure to some special events, also called stroke triggers, can precipitate the onset of ischemic stroke (IS). Previous studies have presented preliminary hypotheses about sexual intercourse as a trigger of IS in predisposed...
Diagnostically defined insomnia is prevalent, persistent, and associated with a range of negative outcomes in childhood and adolescence. To inform prevention and treatment, we need to identify relevant predictors that can be...
is an important cause of pediatric meningitis. The aim of this study was to analyze the clinical features and outcomes of children with pneumococcal meningitis at our hospital in China, so as to provide basis for improving the...
While the concept of prodromal Parkinson’s disease (PD) is well established, reliable markers for the diagnosis of this disease stage are still lacking. We investigated the functional connectivity of the putamina in a...
Given the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson’s disease (PD) is difficult. Our aims were to examine the plasma metabolomics profiling and their...
Tyrosine kinase inhibitors have improved survival for patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis for old or unfit patients remains poor. In the INCB84344-201...
Acetaminophen is one of the most commonly used analgesic drugs in the United States. However, the outcomes of acute acetaminophen overdose might be very serious in some cases. Therefore, prediction of the outcomes of acute...
