Biomarker reduction correlates with decrease in beta-amyloid DENVER—In patients with early-stage Alzheimer’s disease (AD), treatment with an investigative agent reduced plasma phospho-tau217 (P-tau217)—a...
Babies achieve neuromuscular milestone with daily treatment In a small, open-label study, 29% of babies with Type 1 spinal muscular atrophy (SMA) who received daily doses of risdiplam for 12 months were able to sit without...
Up to one-third of patients undergoing cardiac resynchronization therapy (CRT) are nonresponders. Multipoint bicathodic and cathodic-anodal left ventricle (LV) stimulations could overcome this clinical challenge, but their...
Daridorexant is a new dual orexin receptor antagonist currently in late-stage clinical development for the treatment of insomnia. This randomized, double-blind, placebo-controlled, four-period crossover study investigated the...
Limited evidence is available regarding the association between obstructive sleep apnea (OSA) and coronary plaque assessed using quantitative coronary computed tomographic angiography (CCTA).Are there any associations of OSA...
Sleep spindles have an important role in the pathophysiology and perception of sleep. We aimed to investigate the link between sleep spindles and microstructural architecture of sleep in regard to psychiatric characteristics in...
Artificial intelligence (AI) and digital twin models of various systems have long been used in industry to test products quickly and efficiently. Use of digital twins in clinical medicine caught attention with the development of...
Variants in have recently been reported to cause a neurodevelopmental disorder with hypotonia, seizures and impaired language; however, only six variants have been reported and the clinical characteristics have only broadly been...
Perturbations in organellar health can lead to an accumulation of unwanted and/or damaged organelles that are toxic to the cell and which can contribute to the onset of neurodegenerative diseases such as Parkinson’s...
Oxidative stress damage plays a pivotal role in Parkinson’s disease (PD) pathogenesis. Previously, we developed a blood brain barrier-penetrating peptide-based “Trojan Horse” strategy to deliver...
Various pathologies result from disruptions to or stress of endoplasmic reticulum (ER) homeostasis, such as Parkinson’s disease and most neurodegenerative illnesses, diabetes, pulmonary fibrosis, viral infections and...
The safest mode of delivery for very preterm infants is an ongoing topic of debate. There are many reasons for cesarean delivery (CD) in extremely preterm and very preterm infants, including labor, fetal distress, maternal...
