Can an Assay Spot Parkinson’s Disease Before Symptoms Appear?
CSF test shows promise in prodromal PD, dementia with Lewy bodies Measurement of misfolded...
Mar 4, 2021
CSF test shows promise in prodromal PD, dementia with Lewy bodies Measurement of misfolded...
Mar 4, 2021
Mandibular advancement device (MAD) therapy is the most commonly used second-line treatment for obstructive sleep apnea (OSA), but MAD may be ineffective in a subgroup of patients. We describe the use of a trial of a titratable...
Mar 4, 2021
Obstructive sleep apnea (OSA) is a sleep‑related disorder characterized by chronic intermittent hypoxia (CIH). Previous studies have found that intermittent hypoxia promotes drug resistance, cell proliferation, migration and...
Mar 4, 2021
Dysfunction of the sleep-wake transition is considered to be associated with the pathology of patients with primary insomnia (PI). Previous animal study had reported that brain circuits between the striatum and cortex can...
Mar 4, 2021
Some of the most difficult issues in the care of people living with epilepsy (PWE) regard the definition, treatment, and communication of unexpected increase(s) in seizure frequency over a relatively short duration of time. In...
Mar 4, 2021
Therapies for psychiatric and neurological disorders have been in the development and refinement process for the past 5 decades. Yet, most of these therapies lack optimal therapeutic efficacy and have multiple debilitating side...
Mar 4, 2021
Orthologs of human glucocorticoid receptor (GR) and human mineralocorticoid receptor (MR) first appear in cartilaginous fishes. Subsequently, the MR and GR diverged to respond to different steroids: the MR to aldosterone and the...
Mar 4, 2021
When conducting clinical trials comparing over-the-counter (OTC) medications, the wide availability of these treatments are a potential challenge to maintaining study integrity. We seek to describe adherence to a study protocol...
Mar 4, 2021
Hinged total knee arthroplasty (TKA) implants are a commonly used option during revision or even primary surgery, but their complications are not as well-known due to the rapid adoption of gliding implants. The literature is...
Mar 4, 2021
Carfentanil is an ultra-potent opioid with an analgesic potency 10,000 times that of morphine but has received little scientific investigation. In the present study, the human cytochrome P450 (CYP) isozymes catalyzing the...
Mar 4, 2021
No national data exist on hospice medication shortages, the frequency that opioid medications go missing, and drug disposal practices.To provide national estimates for hospices on: drug shortages; frequency of missing...
Mar 4, 2021
Opioid use disorder (OUD) creates significant public health and economic burdens worldwide. Therefore, understanding the risk factors that lead to the development of OUD is fundamental to reducing both its prevalence and its...