Multiple Avenues Mapped for Resistance to Novel KRAS G12C Inhibitor
Diverse genomic, histologic mechanisms impart resistance to single-agent adagrasib ...
Oncology / Hematology
Radioligand Tx Extends PFS for Castration-Resistant Prostate Cancer
VISION trial supports efficacy of 177Lu-PSMA-617 in combination with standard therapy Patients...
JAVELIN Ovarian 200: Avelumab Shows No Survival Benefit
Given either alone or in combination with chemotherapy PFS, OS not improved, study suggests...
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
The type I interferon (IFN) pathway is a key component of innate immune response upon invasion of foreign pathogens. It is also under precise control to prevent excessive upregulation and undesired inflammation cascade. In the...
Prognostic impact of socioeconomic status compared to overall stage for HPV-negative head and neck squamous cell carcinoma.
To estimate the relative prognostic ability of socioeconomic status (SES) compared to overall stage for HPV-negative head and neck squamous cell carcinoma (HNSCC) MATERIALS AND METHODS: Data were obtained from the Carolina Head...
T-cell responses and combined immunotherapy against human carbonic anhydrase 9-expressing mouse renal cell carcinoma.
Renal cell carcinoma (RCC) is known to respond to immune checkpoint blockade (ICB) therapy, whereas there has been limited analysis of T-cell responses to RCC. In this study, we utilized human carbonic anhydrase 9 (hCA9) as a...
Machine Learning-Enabled Renal Cell Carcinoma Status Prediction Using Multiplatform Urine-Based Metabolomics.
Renal cell carcinoma (RCC) is diagnosed through expensive cross-sectional imaging, frequently followed by renal mass biopsy, which is not only invasive but also prone to sampling errors. Hence, there is a critical need for a...
Epigenetic silencing of ZBTB28 promotes renal cell carcinogenesis.
Zinc finger and BTB domain-containing protein 28 (ZBTB28) is a potential tumor suppressor for some cancers. However, its epigenetic regulation and functions in renal cell carcinoma (RCC) remain to be elucidated.The expression of...
Hypofractionated radiotherapy recommendations for localized prostate cancer in Brasil.
Several prospective randomized trials have shown that hypofractionation has the same efficacy and safety as the conventional fractionation in the treatment of localized prostate cancer. There are many benefits of...
Ga-prostate-specific membrane antigen (PSMA) PET/CT as a clinical decision-making tool in biochemically recurrent prostate cancer.
PSMA PET/CT has demonstrated superior sensitivity over conventional imaging in the detection of local and distant recurrence in biochemically relapsed (BCR) prostate cancer. We prospectively investigated the management impact of...
Clinical Utility of Subclassifying Positive Surgical Margins at Radical Prostatectomy.
To determine whether sub-classification of positive surgical margins increases predictive ability for biochemical recurrence and aids clinical decision making in patients undergoing radical prostatectomy.We studied 2,147 pT2 and...
The lncRNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.
Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due to late diagnosis and resistance to chemotherapy, the 5-year survival rate in patients with OC is below 40%. We observed that UCA1 a...
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