Exploring Healthcare Super-Utilization in Gynecologic Oncology
Unplanned acute care continues to be a major contributor to growing healthcare costs in the United...
OB/GYN
Postpartum ultrasound for the diagnosis of obstetric anal sphincter injury.
This review presents the available data on the diagnosis of obstetric anal sphincter injury (OASI) by postnatal ultrasound imaging. There is increasing evidence that anal sphincter tears are often missed after childbirth and,...
Mechanism and Priority of Botulinum Neurotoxin A versus Sacral Neuromodulation for Refractory Overactive Bladder: A Review.
The treatment of common overactive bladder (OAB) has reached a consensus, but there is not a clear answer to the treatment of refractory OAB (ROAB). ROAB is defined as nonresponsive to treatment with behavioural and oral...
Is Lupus Anticoagulant a Significant Feature of COVID-19? A Critical Appraisal of the Literature.
The term “lupus anticoagulant (LA)” identifies a form of antiphospholipid antibodies (aPLs) causing prolongation of clotting tests in a phospholipid concentration-dependent manner. LA is one of the laboratory...
Anti-Xa Monitoring of Low-Molecular-Weight Heparin during Pregnancy: A Systematic Review.
Low-molecular-weight heparin (LMWH) is commonly used for preventing or treating venous thromboembolic disease (VTE) during pregnancy. The physiological changes in maternal metabolism have led to discussions on optimal LMWH...
Potential Strategies to Increase Gynecologic Oncologist Treatment for Ovarian Cancer.
Evidence shows that treatment by gynecologic oncologists (GOs) increases overall survival among women with ovarian cancer. However, specific strategies for institutions and community-based public health programs to promote...
Real-world experience with trabectedin for the treatment of recurrent ovarian cancer.
: The efficacy and safety of trabectedin/pegylated liposomal doxorubicin (trabectedin/PLD) in patients with recurrent ovarian cancer have been demonstrated in randomized clinical studies. Real-world evidence is a subsequent...
[Clinical applications of bevacizumab in the treatment of colorectal and ovarian cancer.]
The development of biological drugs, which began in the 1980s, has revolutionized the treatment of numerous oncological diseases and severely disabling autoimmune diseases, with widely demonstrated evidence of benefit. Today,...
LRH-1 high expression in the ovarian granulosa cells of PCOS patients.
Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders with heterogeneity. There are also reports that liver receptor homolog 1 [LRH-1 or nuclear receptor subfamily 5 group A member 2] plays an...
Elevated Anti-Müllerian Hormone Levels in Newborns of Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis Based on Observational Studies.
We performed this updated systematic review and meta-analysis to evaluate anti-Müllerian hormone levels (AMH) in newborns of mothers with polycystic ovary syndrome (PCOS) compared with healthy controls. A search of the...
Dissection of phospholipases A reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria.
Cationic peptides bio-inspired by natural toxins have been recognized as an efficient strategy for the treatment of different health problems. Due to the specific interaction with substrates from biological membranes, snake...
Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.
Breast cancer remains one of the leading cancers among women. Cancer stem cells (CSCs) are tumor-initiating cells which drive progression, metastasis, and reoccurrence of the disease. CSCs are resistant to conventional chemo-...
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