Measuring medication adherence in children with inflammatory bowel disease (IBD) is difficult due to the complexity of individualized treatment regimens and the growing use of biologic mono- and combination therapy. The gold standard for measuring adherence is electronic monitoring; however, it is ineffective for daily monitoring when several drug formulations and vitamins/supplements are administered. Although validated subjective measures are available, they are not intended for daily usage and do not capture day-to-day adherence change. 

A new technique of evaluating adherence, regardless of a patient’s unique prescription regimen, is given in the following article. Using a micro-longitudinal approach, 30 days of daily self-reported medication adherence data from kids with IBD was obtained through text message. The findings mirror the mean adherence rates from studies that used pill counts and electronic monitoring, indicating that the use of self-reported daily diaries to measure medication adherence in juvenile IBD has potential. 

Reference: https://journals.lww.com/jpgn/Abstract/2020/09000/A_Micro_longitudinal_Approach_to_Measuring.15.aspx