A single dose of the measles-mumps-rubella (MMR) vaccine has been used in regular vaccinations for children in China; however, the Immunoglobulin G (IgG) antibody level of mumps in children aged kindergarten to early school age with a history of MMR vaccine immunization has not been determined. For this study researchers wanted to define the immune profile of children from kindergarten to early elementary school age in order to identify the vulnerable group. A cross-sectional study of 4- to 8-year-old children who had received at least one dose of MMR vaccination was done in Jiangsu Province. The cutoff parameters for the Enzyme-Linked Immunosorbent Assay (ELISA) and the mixture model were used to examine IgG antibody data. A total of 7,436 eligible students were enrolled: 3,386 in kindergarten and 4,450 in primary school. Mumps antibody seroprevalence (75.4%, 95% CI: 74.4% -76.4%) and Geometric mean concentration (GMC, 201.4U/ml, 95%CI: 194.1–209.4) were both low in 2016. The seroprevalence of kindergarten children (78.1%, 95% CI: 76.6% -79.4%) was substantially greater than that of primary school children (73.2%, 95% CI: 71.2% -74.6%). The GMC was shown to be inversely linked to the time of inoculation (F = 32.17, P = 0.002). The mixture model provides a more thorough view of serological data by evaluating four levels of antibody response, implying that a tiny percentage of the population has decreased immunity.
Mumps infection was more likely among kindergarten and primary school children who had received one dose of MMR vaccination, especially in the 7-year-old group in the central area. As a result, a two-dose MMR vaccine schedule should be established since the single-dose MMR vaccine schedule has a limited influence on mumps control and prevention.
Reference:www.tandfonline.com/doi/full/10.1080/21645515.2018.1480239
