The literature on predictors of health-related quality of life (HRQL) was contentious. Researchers performed a review to find HRQL predictors in patients with chronic obstructive pulmonary disease in order to achieve this aim. The research included all publications published up until the end of 2016, which met our inclusion criteria. These characteristics were classified into five categories: demographic factors, comorbidity, disease-related factors, psychological issues, and other factors. Age, disease severity stage, dyspnea grade, and a number of exacerbations were the most prevalent predictors of HRQL in individuals with chronic obstructive pulmonary disease. Comorbidity, gender, body mass index, socioeconomic situation, and educational level are other deciding variables. This assessment of scant but well-designed literature provides an up-to-date state-of-the-art that may be relevant for future study.