Hydroxychloroquine (HCQ)-induced AGEP or acute generalized exanthematous pustulosis is poorly described in different studies. This particular study aimed to characterize the laboratory, clinical, genetic, and allergological features of HCQ‐induced AGEP. The researchers and doctors conducted a retrospective study of patients diagnosed with HCQ‐induced AGEP between 2011 and 2019. We performed a molecular analysis to identify variations in the IL36RN gene. We also reviewed similar cases reported between 1991 and March 2020.

The researchers included seven patients for the study. The average age was 47 years old, and the meantime from HCQ beginning to the onset of symptoms was 40 days. All patients received topical steroids with a full resolution of the rash within an average of 39 days after HCQ withdrawal. They performed patch tests on three patients with positive results in one case. Genetic analyses were performed for three patients, and no mutation in the IL36RN gene was identified. The latent period and the duration for resolution of HCQ‐induced AGEP can be more extended than with other drugs due to the metabolic characteristics of HCQ. Mutations in the IL36RN gene were not identified in our patients. However, the doctors are still doing some more researchers to characterize all the features of HCQ-induced.

Ref: https://onlinelibrary.wiley.com/doi/10.1111/ijd.15419