One of the obstacles to the effectiveness of vaccination programs is vaccine shortages at health institutions, which can occur as a result of poor vaccine stock management. Countries have devised a variety of ways to better manage vaccination stocks. This review highlights the present state of knowledge about vaccine stock management initiatives. To be eligible for inclusion in this review, researchers evaluated both randomized trials and non-randomized research. PubMed, Embase, Cochrane Central Register of Controlled Trials, World Health Organization Library Information System, Web of Science, and PDQ-Evidence were among the resources searched. They looked through the World Health Organization, the Global Alliance for Vaccine and Immunization, PATH’s Vaccine Resources Library, and the United Nations Children’s Fund websites. All of the included studies’ reference lists were also searched. Two writers independently screened search results, examined full texts of possibly suitable publications, assessed bias risk, and extracted data, reaching consensus on differences. 

Inclusion criteria were satisfied by four studies. Three studies were carried out in low- and middle-income nations, while one was carried out in Canada. All of the studies had different limitations and were rated as having a high risk of bias. The study’s findings indicate that using digital information systems to improve information and stock visibility, in conjunction with other interventions, has the potential to increase vaccine availability, reduce response times, and improve vaccine record quality.