For a study, researchers sought to understand that the clinical appearance, diagnosis, medicinal and surgical therapy, and results of pediatric musculoskeletal coccidioidomycosis at a tertiary care hospital are described in one of the biggest case series available. A review case survey was performed on patients less than equal to 21 years of age who were followed at a tertiary consideration place with a conclusion of outer muscle coccidioidomycosis from January 1, 2007, to December 31, 2020. Graphic information was communicated as medians and interquartile range (IQR) for persistent factors or as recurrence and rate for clear-cut factors. Straight-out values were analyzed utilizing the χ2 test. About 41 patients were distinguished. The median age was 12.8 years, and most were male (71%), Latinx (66%), and healthy (71%). Limb swelling (66%), bone pain (54%), and joint pain (46%) were the most common presenting symptoms. Multiple bone involvement was present in 29%, while 12% had the joint disease, and craniofacial (n = 10) and metacarpal/metatarsal bones (n=9) were the most commonly involved sites. Elevated Coccidioides complement fixation (CF) titers ≥1:32 were seen in 90% of the patients. About 33 patients (81%) required careful intercessions, and of these, 16 (48%) required extra surgeries. About 11 patients (27%) had disease relapse. Kids more than 13 years old were bound to have more than 1 organ association (16 vs. 7, P=0.04), various bone inclusion (10 vs. 2, P=0.004), and greatest Coccidioides CF titers more than 1:128 (13 vs. 6, P=0.02). In endemic regions, outer muscle coccidioidomycosis causes significant illness trouble in kids. It should be viewed as the differential conclusion of those giving bone and joint aggravation or expanding. Early findings and treatment were fundamental to limiting long-haul horribleness and mortality.