Castleman disease (CD) is a lymphoproliferative B‐cell disease diagnosed from lymphoid hyperplasia with vascular proliferation. Symptoms may include fever, night sweats, and weight loss. Cutaneous manifestations often may go unnoticed since little has been described in the literature regarding them. The researchers have performed a CD search with cutaneous manifestations in PUBMED, ProQuest, Ovid, Scopus, EMBASE, and Medline. All articles included patients over 18 years of age with a diagnosis of CD and cutaneous manifestations.

The researchers have included a total of 68 articles. The most common cutaneous manifestations include paraneoplastic pemphigus and erythematous‐brown plaques, papules, or nodules. Patients presenting with these manifestations should always have a thorough physical exam, and clinicians should try to identify any palpable lymph nodes. A complete workup to rule out other neoplasias needs to be performed as well. A better understanding of these skin manifestations of CD may help physicians promptly diagnose and reconsider the path of diagnostic tests to identify this entity. However, the researchers and doctors are continuing their studies to find some new outcomes for the betterment of the medical treatment. The researchers and top-level doctors are considering all types of information related to Cutaneous manifestations.

Ref: https://onlinelibrary.wiley.com/doi/10.1111/ijd.15043